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March Madness has thrown up some shocking results over the years, but the five games we have picked out are the biggest upsets of all time.
The games on this list tested the patience of players, coaches and fans as multiple overtimes led to games comfortably passing the three-hour mark.
Discover more about the history of the NCAA Championship in College Basketball, including how it became what we now call March Madness.
What makes a successful college basketball program? We take a look at some of the most successful of all time to find the greatest ever.